seroquel side effects :: Article Creator Seroquel Xr Seroquel Xr Generic Name & Formulations General Description Quetiapine (as fumarate) 50mg, 150mg, 200mg, 300mg, 400mg; ext-rel tabs. Pharmacological Class Dibenzothiazepine. How Supplied XR—60; Tabs 25mg, 50mg, 100mg, 200mg, 400mg—100; 300mg—60 Storage Store at 25ºC (77ºF); excursions permitted to 15-30ºC (59-86ºF). Mechanism of Action The efficacy of quetiapine in these indications could be mediated through a combination of dopamine type 2 (D2) and serotonin type 2A (5HT2A) antagonism. The active metabolite, N-desalkyl quetiapine (norquetiapine), has similar activity at D2, but greater activity at 5HT2A receptors, than the parent drug (quetiapine). Seroquel Xr Indications Indications Acute treatment of manic or mixed episodes in bipolar I disorder, as monotherapy and as an adjunct to lithium or divalproex. Depressive episodes associated with b...