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hypertension medications :: Article Creator Pathophysiology Of Pulmonary Arterial Hypertension Panelists discuss how the pathophysiology of pulmonary arterial hypertension involves complex mechanisms across multiple genetic and treatment pathways, with over 20 identified genes and four major therapeutic targets including nitric oxide, endothelin, prostacyclin, and activin signaling inhibition. Pathophysiology and Treatment Pathways Pulmonary arterial hypertension (PAH) represents a complex disease with multifaceted pathophysiology involving over 20 identified genetic mutations that can contribute to disease development. The condition affects pulmonary vasculature and capillaries, causing narrowing that increases workload on the right ventricle and heart. Understanding these underlying mechanisms is crucial for effective disease management and treatment selection. From a therapeutic perspective, PAH management has evolved to target four disti...