Patient Case Study: A Rare Neurological Disease Diagnostic Journey
Side Effect(s) Of Telmisartan And Hydrochlorothiazide
Review the side-effects of Telmisartan and Hydrochlorothiazide as documented in medical literature. The term "side effects" refers to unintended effects that can occur as a result of taking the medication. In majority of the instances these side-effects are mild and easily tolerable, however sometimes they can be more severe and can be detrimental. If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist. Body as a Whole - Fatigue, influenza-like symptoms.Central Nervous System - Dizziness.
Gastrointestinal - Diarrhea, nausea.
Respiratory - Sinusitis, upper respiratory tract infection
Other Precautions : * Avoid excess dosage.Side Effects Of Tezspire: What You Need To Know
Tezspire (tezepelumab-ekko) is a prescription drug that's used with other medications to treat severe asthma in adults and some children. Tezspire can cause side effects that range from mild to serious. Examples of common side effects include back and joint pain.
The active ingredient in Tezspire is tezepelumab-ekko.* (An active ingredient is what makes a drug work.) Tezspire comes as a liquid solution that's given as an injection under your skin. You may administer doses yourself, or they may be given by a healthcare professional.
Keep reading to learn about the common, mild, and serious side effects that Tezspire can cause. For a general overview of the drug, including details about its uses, see this article.
* The reason "-ekko" appears at the end of the drug's name is to show that the drug is distinct from similar medications that may be created in the future.
Some people may experience mild to serious side effects during treatment with Tezspire. Some side effects are more common than others, but side effects won't happen to everyone.
Examples of Tezspire's commonly reported side effects include:
This is not a complete list of side effects. Keep reading to learn more about mild to serious side effects this drug may cause.
* To learn more about this side effect, see the "Side effects explained" section below.
Tezspire can cause mild side effects in some people. In most cases, these are temporary, and some may be easily managed.
Examples of mild side effects that have been reported with this drug include:
* To learn more about this side effect, see the "Side effects explained" section below.
If you have side effect symptoms that are ongoing or bother you, talk with your doctor or pharmacist. But do not stop Tezspire treatment unless your doctor recommends it.
Tezspire may cause mild side effects other than those listed above. See the drug's prescribing information for details.
Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. If you'd like to notify the FDA about a side effect you've had with Tezspire, visit MedWatch.
Serious side effects can occur with Tezspire, such as allergic reaction,* but they are rare. This drug is given as an injection. It may be administered by a healthcare professional who will monitor you afterward for any signs of allergic reaction. You may be able to administer the drug yourself once you're comfortable doing so.
If you develop serious side effects from Tezspire outside of the doctor's office, call your doctor right away. If the side effects seem life threatening or you think you're having a medical emergency, immediately call 911 or your local emergency number.
Talk with your doctor or pharmacist to learn more about possible serious side effects of Tezpire.
* To learn more about this side effect, see the "Side effects explained" section below.
Learn more about some of the side effects Tezspire may cause.
Injection site side effectsTezspire is a drug that's given as an injection under your skin in areas such as your upper arm, belly, or thigh. Reactions at the injection site can occur in some people, but they aren't common and are usually mild.
Symptoms of injection site reactions with Tezspire include:
To see how often injection site side effects occurred in studies, check out the drug's prescribing information.
What might helpYou'll receive a Tezspire injection once every 4 weeks. To help prevent site reactions, injection sites may be rotated. Any area of your skin that's tender, bruised, or discolored should be avoided for the injection.
Injection site reactions are usually temporary. But if your symptoms don't go away or are bothersome, ask your doctor for recommendations to help ease them.
Sore throatSore throat was a commonly reported Tezspire side effect in the drug's studies. Some sore throat symptoms were associated with bacterial and viral infections.
Swelling and soreness in the throat cause your throat to feel raw, dry, or scratchy. Your throat may be irritated or tender and have a burning sensation. You may have pain when you swallow or talk.
What might helpIn most cases, your sore throat will be temporary. If it's linked to a bacterial infection, your doctor may treat you with antibiotics.
To help ease your symptoms:
Your doctor or pharmacist may recommend over-the-counter (OTC) drugs such as acetaminophen (Tylenol), ibuprofen (Advil, Motrin), or an antiseptic throat spray.
Joint painJoint pain was a commonly reported side effect in Tezspire studies. Discomfort, soreness, aches, and pain may occur in joints such as the shoulders, knees, elbows, wrists, and hips.
What might helpTalk with your doctor if you are concerned about joint pain from Tezspire. They may recommend that you apply heat or ice to the area to help ease your pain, or to wrap the joint with a brace.
There are some OTC medications that treat joint pain. Your doctor or pharmacist may recommend a specific medication, such as ibuprofen (Advil, Motrin).
Allergic reactionLike most drugs, Tezspire can cause an allergic reaction in some people. Symptoms can be mild to serious and can include:
A severe allergic reaction called anaphylaxis has occurred in some people using Tezspire. But this was reported after the drug was approved for use. Severe reactions may occur within hours to days after receiving a dose of Tezspire.
What might helpIf you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. They may suggest a treatment to manage your symptoms. Examples include:
If your doctor confirms you've had a mild allergic reaction to Tezspire, they'll decide whether you should continue using it.
If you have symptoms of a severe allergic reaction, such as swelling or trouble breathing, call 911 or your local emergency number right away. These symptoms could be life threatening and require immediate medical care.
If your doctor confirms you've had a serious allergic reaction to Tezspire, they may have you switch to a different treatment.
Keeping track of side effects
During your Tezspire treatment, consider taking notes on any side effects you're having. You can then share this information with your doctor. This is especially helpful when you first start taking new drugs or using a combination of treatments.
Your side effect notes can include things such as:
Keeping notes and sharing them with your doctor will help them learn more about how Tezspire affects you. They can then use this information to adjust your treatment plan if needed.
Tezspire may not be right for you if you have certain medical conditions. (This is known as a drug-condition interaction.) Other factors may also affect whether Tezspire is a good treatment option for you. Talk with your doctor about your health history and possible side effects and risks of Tezspire before starting treatment. Factors to consider include those described below.
Infection caused by worms. Tezspire may affect medications used to treat infections caused by worms. If you have a worm-related infection, your doctor will likely treat it before you start Tezspire. If you get infection during your treatment, your doctor may temporarily have you stop Tezspire until the infection is treated.
Allergic reaction. If you've had an allergic reaction to Tezspire or any of its ingredients, your doctor will likely not prescribe it for you. Ask them about other medications that might be better options. (For more information, see "Allergic reaction" under "Side effects explained" above.)
Alcohol and TezspireIt's not known whether alcohol interacts with Tezspire, but alcohol can make your asthma symptoms worse. If you drink alcohol, talk with your doctor about what amount, if any, is safe for you to consume while using Tezspire.
Pregnancy and breastfeeding with TezspireThe safety of Tezspire during pregnancy and breastfeeding is not known. But Tezspire belongs to a group of drugs called monoclonal antibodies, which can pass from the mother to the fetus and also through breast milk. How the drug affects a fetus or a breastfeeding child is unknown.
Talk with your doctor about how to treat your asthma if you're breastfeeding, pregnant, or planning either. They can give you more information on treatment options, birth control, and the best way to feed your child.
Some Tezspire side effects are common, but they're usually mild.
Talking with your doctor about Tezspire's possible side effects can help you feel more confident with your treatment. Below are a few questions that may help you get the conversation started.
For information on different conditions and tips for improving your health, subscribe to any of Healthline's newsletters. You may also want to check out the online communities at Bezzy. It's a place where people with certain conditions can find support and connect with others.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
Eligard Side Effects: What You Should Know
Eligard is a brand-name injectable drug prescribed to help manage symptoms of advanced prostate cancer in adults. As with other drugs, Eligard can cause side effects, such as fatigue, hot flashes, and tumor flares.
Eligard can cause certain side effects, some of which are more common than others. These side effects may be temporary, lasting a few days to weeks after each Eligard injection.* However, if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor.
These are just a few of the more common side effects reported by adult males† who received Eligard in clinical trials:
* Eligard is given by a doctor or other healthcare professional as a subcutaneous injection.† Sex and gender exist on spectrums. Use of the term "male" in this article refers to sex assigned at birth.
Mild side effects can occur with Eligard treatment. This list doesn't include all possible mild side effects of the drug. For more information, you can refer to Eligard's prescribing information.
Mild side effects that have been reported with Eligard include:
These side effects may be temporary, lasting a few days to weeks after each Eligard dose. (Eligard is given as a subcutaneous injection.) However, if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor.
Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. If you develop a side effect during Eligard treatment and want to tell the FDA about it, visit MedWatch.
* For more information about this side effect, see "Side effect specifics" below.† An allergic reaction is possible after using Eligard. However, it's not clear whether this side effect occurred in clinical trials. To learn more, see the "Side effect specifics" section below.
Eligard may cause serious side effects. The list below may not include all possible serious side effects of the drug. For more information, you can refer to Eligard's prescribing information.
If you develop serious side effects during Eligard treatment, call your doctor right away. If the side effects seem life threatening or you think you're having a medical emergency, immediately call 911 or your local emergency number.
Serious side effects that have been reported and their symptoms include:
* There have been rare reports of this side effect since Eligard and similar drugs were approved for use. Your doctor can provide more information about your risk of these side effects with Eligard.† For more information about this side effect, see "Side effect specifics" below.‡ An allergic reaction is possible after using Eligard. However, it's not clear whether this side effect occurred in clinical trials. To learn more, see the "Side effect specifics" section below.
Eligard may cause several side effects. Here are some frequently asked questions about the drug's side effects and their answers.
Will side effects of Eligard go away?Possibly. Some of the drug's side effects may be temporary and go away within a few weeks after each Eligard dose. Examples include dizziness and nausea.
However, because of the way Eligard works, certain side effects may persist as long as you receive the drug. These include erectile dysfunction (ED) and testicular atrophy (decreased testicle size).* (To learn more about the way Eligard works, see the "How it works" section of this article.)
If the side effects don't go away, bother you, or become severe, be sure to talk with your doctor.
* ED and testicular atrophy are serious side effects of Eligard. For more information, see the "Serious side effects of Eligard" section above.
When do side effects of Eligard start? And how long do they last?Side effects of Eligard can start at any time during treatment. Some side effects go away within a few weeks, but they may last longer. (To learn more, see the question "Can Eligard cause long-term side effects?" below.)
For example, tumor flares* may occur with Eligard treatment. A tumor flare refers to an increase in prostate cancer symptoms due to a rise in testosterone levels. In Eligard's clinical trials, tumor flares started about week 2 of treatment and began subsiding about week 4.†
It's also possible for side effects to start after Eligard treatment ends. This is because the drug stays in your body for up to a year after your last dose.
If you have questions about what to expect with Eligard treatment, talk with your doctor for more information.
* This is a serious side effect of Eligard. To learn more, see the "Side effect specifics" section below.† For more information about Eligard's dosing schedule, see the "Dosage" section of this article.
Can Eligard cause long-term side effects?Yes, on rare occasions, Eligard can cause long-term side effects. These side effects may occur during treatment but cause problems that persist after treatment ends. Examples of possible long-term side effects with Eligard include:
For more information about Eligard and its long-term side effects, talk with your doctor.
Note: Possible long-term side effects listed above are all serious side effects of Eligard. For details, see the "Serious side effects of Eligard" section above.
Learn more about some of the side effects that Eligard may cause. To find out how often side effects occurred in clinical trials, see the prescribing information for Eligard.
Weight gainEligard treatment may cause weight gain, but this side effect wasn't common in the drug's clinical trials.
Eligard works by lowering the level of testosterone in your body. This is a hormone that helps prostate cancer grow. Having low testosterone may lead to an increase in body fat, which could result in weight gain. The amount of weight gain can vary between people depending on the Eligard dose and other factors.
What you can doYou and your doctor will monitor your weight during Eligard treatment. Your doctor may also recommend a body weight that's safe and healthy for you during Eligard treatment.
Tell your doctor if you notice unexpected weight gain while receiving Eligard. Your doctor will help determine the cause.
In some cases, your doctor may suggest some safe ways to lose or maintain your weight, such as proper nutrition and exercise. For more information about weight management, talk with your doctor.
Tumor flaresSome people who received Eligard in clinical trials experienced a tumor flare. With this side effect, prostate cancer cells grow and symptoms may worsen. A tumor flare may begin within 1–2 weeks of starting Eligard.
Eligard can cause a tumor flare because of how the drug works to help manage symptoms of advanced prostate cancer.
Eligard treatment lowers the level of testosterone, a hormone that helps prostate cancer grow. By lowering testosterone levels, Eligard slows cancer growth and helps relieve cancer symptoms. However, before testosterone levels decrease with Eligard, they initially increase. This temporary rise in testosterone triggers a tumor flare.
A tumor flare may lead to severe effects in certain people. This includes people with a blockage in their urinary tract or whose prostate cancer has spread to the spine.
Symptoms of a tumor flare vary depending on where in your body prostate cancer has spread. Tumor flare symptoms can include:
What you can doDepending on your condition, your doctor may monitor you more closely when you first start Eligard. If you experience new or worsened symptoms, talk with your doctor right away. They'll determine whether additional treatment is needed to ease your symptoms. Or, they may suggest a different medication for your condition.
Keep in mind that most people receiving Eligard in clinical trials did not experience a tumor flare. In addition, tumor flares are usually temporary events. Typically, symptoms start to decrease within 2–4 weeks after starting Eligard.
Talk with your doctor if you'd like more information about tumor flares.
Allergic reactionAs with most drugs, Eligard can cause an allergic reaction in some people. However, it's not clear whether this side effect occurred in clinical trials.
Symptoms can be mild or serious and can include:
For mild symptoms of an allergic reaction, call your doctor right away. They may recommend ways to ease your symptoms and determine whether you should continue with Eligard treatment. However, if your symptoms are serious and you think you're having a medical emergency, immediately call 911 or your local emergency number.
Be sure to talk with your doctor about your health history before you start Eligard. This drug may not be the right treatment option for you if you have certain medical conditions or other factors that affect your health. These are considered drug-condition or drug-factor interactions. The conditions and factors to consider include:
Allergic reaction: If you've had an allergic reaction to Eligard or any of its ingredients, your doctor will likely not prescribe Eligard. Ask your doctor what other medications may be better options for you.
Alcohol consumption: If you drink alcohol, Eligard is likely safe for you. This medication is not known to cause any specific negative effects with alcohol. However, both alcohol and Eligard may cause dizziness and fatigue as side effects. So consuming alcohol during Eligard treatment may worsen the medication's effects.
If you drink alcohol and have questions about how much alcohol is safe to use when taking Eligard, talk with your doctor or pharmacist.
Diabetes: If you have diabetes, tell your doctor before starting Eligard treatment. This drug may cause high blood sugar,* which could worsen diabetes. Your doctor may monitor your blood sugar closely during Eligard treatment.
Cardiovascular conditions or related factors: Before starting Eligard treatment, tell your doctor if you have heart disease or factors that increase your risk of heart disease. Examples include high cholesterol and diabetes. Also tell them if you have any heart conditions, such as heart failure or long QT syndrome.
In addition, Eligard may cause irregular heart rhythm or other cardiovascular events,* including heart attack and stroke. The risk may be higher in people with any of the factors listed above. Your doctor can recommend whether Eligard is a safe treatment option.
Seizures: If you have a condition that causes seizures,* talk with your doctor before starting Eligard treatment. This drug may cause seizures as a side effect. Your risk could be higher if you already have a seizure condition. Your doctor can tell you whether Eligard is a safe treatment option.
Pregnancy or breastfeeding: If you're pregnant or breastfeeding, Eligard may not be safe for your pregnancy or your child. Eligard has not been studied in people who are pregnant or breastfeeding. However, the drug may increase the risk of pregnancy loss. Note that this medication is not approved for use in females.† Eligard is approved to treat advanced prostate cancer in adult males.
* This is a serious side effect of Eligard. To learn more, see the "Serious side effects of Eligard" section above.† Sex and gender exist on spectrums. Use of the terms "male" and "female" in this article refers to sex assigned at birth.
If you'd like to learn more about Eligard, talk with your doctor or pharmacist. They can help answer any questions you have about side effects from taking the drug.
Besides talking with your doctor, you can do some research on your own. These articles might help:
Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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