Vaccines for Children: List By Age, Benefits, Safety
Neurontin Tablets
Neurontin Tablets Generic Name & Formulations General DescriptionGabapentin 600mg, 800mg; scored.
How SuppliedCaps, tabs—100; Soln—470mL
StorageNeurontin Tablets and Capsules:
Neurontin Oral Solution:
The precise mechanisms by which gabapentin produces its analgesic and antiepileptic actions are unknown. Gabapentin is structurally related to the neurotransmitter gamma-aminobutyric acid (GABA) but has no effect on GABA binding, uptake, or degradation. In vitro studies have shown that gabapentin binds with high-affinity to the α2δ subunit of voltage-activated calcium channels; however, the relationship of this binding to the therapeutic effects of gabapentin is unknown.
Neurontin Tablets Indications IndicationsPostherpetic neuralgia.
Neurontin Tablets Dosage and Administration Adult300mg once on day 1, twice daily on day 2, and 3 times daily on day 3; may titrate up to usual max 1.8g/day in 3 divided doses (doses up to 3.6g/day have been used without added benefit). Renal dysfunction: CrCl 30–59mL/min: 400–1400mg/day in 2 divided doses; CrCl 15–29mL/min: 200–700mg once daily; CrCl ≤15mL/min: 100–300mg once daily (see full labeling); hemodialysis: 125–350mg after session.
ChildrenNot established.
Neurontin Tablets ContraindicationsNot Applicable
Neurontin Tablets Boxed WarningsNot Applicable
Neurontin Tablets Warnings/Precautions Warnings/PrecautionsMonitor for DRESS/multiorgan hypersensitivity, anaphylaxis, angioedema; discontinue if occurs. Increased risk of suicidal thoughts/behavior. Monitor for worsening of depression, suicidal thoughts/behavior, and/or unusual changes in mood/behavior. Underlying respiratory depression; monitor and consider initiating at a low dose. Avoid abrupt cessation. Renal impairment. Elderly. Pregnancy. Nursing mothers.
Neurontin Tablets Pharmacokinetics EliminationRenal. Half-life: 5–7 hours.
Neurontin Tablets Interactions InteractionsIncreased risk for serious respiratory depression and sedation when concomitant CNS depressants, opioids (eg, morphine, hydrocodone, oxycodone, buprenorphine). Give 2hrs after antacids. May antagonize hydrocodone. May interfere with some urine protein tests (eg, Multistix-SG).
Neurontin Tablets Adverse Reactions Adverse ReactionsDizziness, somnolence, peripheral edema, nausea, ataxia, amblyopia, thought disorder, abnormal gait, incoordination.
Neurontin Tablets Clinical TrialsSee Literature
Neurontin Tablets NoteNot Applicable
Neurontin Tablets Patient CounselingSee Literature
Neurontin Tablets Generic Name & Formulations General DescriptionGabapentin 600mg, 800mg; scored.
How SuppliedCaps, tabs—100; Soln—470mL
StorageNeurontin Tablets and Capsules:
Neurontin Oral Solution:
The precise mechanisms by which gabapentin produces its analgesic and antiepileptic actions are unknown. Gabapentin is structurally related to the neurotransmitter gamma-aminobutyric acid (GABA) but has no effect on GABA binding, uptake, or degradation. In vitro studies have shown that gabapentin binds with high-affinity to the α2δ subunit of voltage-activated calcium channels; however, the relationship of this binding to the therapeutic effects of gabapentin is unknown.
Neurontin Tablets Indications IndicationsAdjunct in partial seizures.
Neurontin Tablets Dosage and Administration AdultAdd or remove other AEDs over at least 1 week. Initially 300mg three times daily. Usual range: 900–1800mg/day in 3 divided doses; max 2.4g/day (up to 3.6g/day has been used short-term; see full labeling); max 12 hrs between doses. Renal dysfunction: CrCl 30–59mL/min: 400–1400mg/day in 2 divided doses; CrCl 15–29mL/min: 200–700mg once daily; CrCl ≤15mL/min: 100–300mg once daily (see full labeling); hemodialysis: 125–350mg after session.
Children<3yrs: not established. Give in 3 divided doses; max 12 hrs between doses; titrate over 3 days. 3–11yrs: initially 10–15mg/kg per day. 3–4yrs: titrate to 40mg/kg per day. ≥5yrs: titrate to 25–35mg/kg per day. Max 50mg/kg per day. Renal impairment: not studied.
Neurontin Tablets ContraindicationsNot Applicable
Neurontin Tablets Boxed WarningsNot Applicable
Neurontin Tablets Warnings/Precautions Warnings/PrecautionsMonitor for DRESS/multiorgan hypersensitivity, anaphylaxis, angioedema; discontinue if occurs. Increased risk of suicidal thoughts/behavior. Monitor for worsening of depression, suicidal thoughts/behavior, and/or unusual changes in mood/behavior. Underlying respiratory depression; monitor and consider initiating at a low dose. Avoid abrupt cessation. Renal impairment. Elderly. Pregnancy. Nursing mothers.
Neurontin Tablets Pharmacokinetics EliminationRenal. Half-life: 5–7 hours.
Neurontin Tablets Interactions InteractionsIncreased risk for serious respiratory depression and sedation when concomitant CNS depressants, opioids (eg, morphine, hydrocodone, oxycodone, buprenorphine). Give 2hrs after antacids. May antagonize hydrocodone. May interfere with some urine protein tests (eg, Multistix-SG).
Neurontin Tablets Adverse Reactions Adverse ReactionsSomnolence, dizziness, ataxia, fatigue, nystagmus; diplopia, amblyopia, tremor, dysarthria, amnesia, back pain; children also: viral infection, fever, nausea, vomiting, emotional lability, thought disorder, hyperkinesia, hostility.
Neurontin Tablets Clinical TrialsSee Literature
Neurontin Tablets NoteNot Applicable
Neurontin Tablets Patient CounselingSee Literature
Neurontin Oral Soln
Neurontin Oral Soln Generic Name & Formulations General DescriptionGabapentin 250mg/5mL; strawberry-anise flavor.
How SuppliedCaps, tabs—100; Soln—470mL
StorageNeurontin Tablets and Capsules:
Neurontin Oral Solution:
The precise mechanisms by which gabapentin produces its analgesic and antiepileptic actions are unknown. Gabapentin is structurally related to the neurotransmitter gamma-aminobutyric acid (GABA) but has no effect on GABA binding, uptake, or degradation. In vitro studies have shown that gabapentin binds with high-affinity to the α2δ subunit of voltage-activated calcium channels; however, the relationship of this binding to the therapeutic effects of gabapentin is unknown.
Neurontin Oral Soln Indications IndicationsPostherpetic neuralgia.
Neurontin Oral Soln Dosage and Administration Adult300mg once on day 1, twice daily on day 2, and 3 times daily on day 3; may titrate up to usual max 1.8g/day in 3 divided doses (doses up to 3.6g/day have been used without added benefit). Renal dysfunction: CrCl 30–59mL/min: 400–1400mg/day in 2 divided doses; CrCl 15–29mL/min: 200–700mg once daily; CrCl ≤15mL/min: 100–300mg once daily (see full labeling); hemodialysis: 125–350mg after session.
ChildrenNot established.
Neurontin Oral Soln ContraindicationsNot Applicable
Neurontin Oral Soln Boxed WarningsNot Applicable
Neurontin Oral Soln Warnings/Precautions Warnings/PrecautionsMonitor for DRESS/multiorgan hypersensitivity, anaphylaxis, angioedema; discontinue if occurs. Increased risk of suicidal thoughts/behavior. Monitor for worsening of depression, suicidal thoughts/behavior, and/or unusual changes in mood/behavior. Underlying respiratory depression; monitor and consider initiating at a low dose. Avoid abrupt cessation. Renal impairment. Elderly. Pregnancy. Nursing mothers.
Neurontin Oral Soln Pharmacokinetics EliminationRenal. Half-life: 5–7 hours.
Neurontin Oral Soln Interactions InteractionsIncreased risk for serious respiratory depression and sedation when concomitant CNS depressants, opioids (eg, morphine, hydrocodone, oxycodone, buprenorphine). Give 2hrs after antacids. May antagonize hydrocodone. May interfere with some urine protein tests (eg, Multistix-SG).
Neurontin Oral Soln Adverse Reactions Adverse ReactionsDizziness, somnolence, peripheral edema, nausea, ataxia, amblyopia, thought disorder, abnormal gait, incoordination.
Neurontin Oral Soln Clinical TrialsSee Literature
Neurontin Oral Soln NoteNot Applicable
Neurontin Oral Soln Patient CounselingSee Literature
Neurontin Oral Soln Generic Name & Formulations General DescriptionGabapentin 250mg/5mL; strawberry-anise flavor.
How SuppliedCaps, tabs—100; Soln—470mL
StorageNeurontin Tablets and Capsules:
Neurontin Oral Solution:
The precise mechanisms by which gabapentin produces its analgesic and antiepileptic actions are unknown. Gabapentin is structurally related to the neurotransmitter gamma-aminobutyric acid (GABA) but has no effect on GABA binding, uptake, or degradation. In vitro studies have shown that gabapentin binds with high-affinity to the α2δ subunit of voltage-activated calcium channels; however, the relationship of this binding to the therapeutic effects of gabapentin is unknown.
Neurontin Oral Soln Indications IndicationsAdjunct in partial seizures.
Neurontin Oral Soln Dosage and Administration AdultAdd or remove other AEDs over at least 1 week. Initially 300mg three times daily. Usual range: 900–1800mg/day in 3 divided doses; max 2.4g/day (up to 3.6g/day has been used short-term; see full labeling); max 12 hrs between doses. Renal dysfunction: CrCl 30–59mL/min: 400–1400mg/day in 2 divided doses; CrCl 15–29mL/min: 200–700mg once daily; CrCl ≤15mL/min: 100–300mg once daily (see full labeling); hemodialysis: 125–350mg after session.
Children<3yrs: not established. Give in 3 divided doses; max 12 hrs between doses; titrate over 3 days. 3–11yrs: initially 10–15mg/kg per day. 3–4yrs: titrate to 40mg/kg per day. ≥5yrs: titrate to 25–35mg/kg per day. Max 50mg/kg per day. Renal impairment: not studied.
Neurontin Oral Soln ContraindicationsNot Applicable
Neurontin Oral Soln Boxed WarningsNot Applicable
Neurontin Oral Soln Warnings/Precautions Warnings/PrecautionsMonitor for DRESS/multiorgan hypersensitivity, anaphylaxis, angioedema; discontinue if occurs. Increased risk of suicidal thoughts/behavior. Monitor for worsening of depression, suicidal thoughts/behavior, and/or unusual changes in mood/behavior. Underlying respiratory depression; monitor and consider initiating at a low dose. Avoid abrupt cessation. Renal impairment. Elderly. Pregnancy. Nursing mothers.
Neurontin Oral Soln Pharmacokinetics EliminationRenal. Half-life: 5–7 hours.
Neurontin Oral Soln Interactions InteractionsIncreased risk for serious respiratory depression and sedation when concomitant CNS depressants, opioids (eg, morphine, hydrocodone, oxycodone, buprenorphine). Give 2hrs after antacids. May antagonize hydrocodone. May interfere with some urine protein tests (eg, Multistix-SG).
Neurontin Oral Soln Adverse Reactions Adverse ReactionsSomnolence, dizziness, ataxia, fatigue, nystagmus; diplopia, amblyopia, tremor, dysarthria, amnesia, back pain; children also: viral infection, fever, nausea, vomiting, emotional lability, thought disorder, hyperkinesia, hostility.
Neurontin Oral Soln Clinical TrialsSee Literature
Neurontin Oral Soln NoteNot Applicable
Neurontin Oral Soln Patient CounselingSee Literature
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