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14 Totally Real Side Effects Of Ambien, According To Dr. Roseanne Barr

Roseanne Barr has claimed that Ambien -- not racism -- was responsible for her racist outburst on Twitter yesterday.

If the simple sleeping pill caused her to spew anachronistic racial epithets in the middle of the night, what else can she blame on it? Here are just a few of the apparent side effects of Ambien, if we are to believe the research conducted by the Roseanne Barr School of Medicine.

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When 'Roseanne' was good Credit: ABC via Getty Images

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Zolpidem Sublingual Tablets

Zolpidem Sublingual Tablets Generic Name & Formulations General Description

Zolpidem tartrate 1.75mg, 3.5mg.

Pharmacological Class

Imidazopyridine hypnotic.

How Supplied

Contact supplier

Mechanism of Action

Zolpidem interacts with gamma-aminobutyric acid-benzodiazepine (GABA-BZ) receptor complex and shares some of the pharmacological properties of benzodiazepines. In vitro, zolpidem binds to the BZ1 receptor preferentially with a high affinity ratio of the α1/α5 subunits.

Zolpidem Sublingual Tablets Indications Indications

As needed treatment of insomnia when a middle-of-the-night awakening is followed by difficulty returning to sleep.

Limitations of Use

Not indicated for treatment of middle-of-the-night insomnia when patient has <4hrs of bedtime remaining before planned time of waking.

Zolpidem Sublingual Tablets Dosage and Administration Adult

Use lowest effective dose. Effects delayed if taken with or after a meal. Place 1 tab under the tongue and allow to disintegrate completely before swallowing. Take only once per night as needed (with at least 4hrs of bedtime remaining before planned time of waking). Women: 1.75mg. Men: 3.5mg. Concomitant CNS depressants, elderly (≥65yrs), hepatic impairment: 1.75mg.

Children

<18yrs: not recommended.

Zolpidem Sublingual Tablets Contraindications Contraindications

Prior history of complex sleep behaviors with zolpidem SL tabs.

Zolpidem Sublingual Tablets Boxed Warnings Boxed Warning

Complex sleep behaviors.

Zolpidem Sublingual Tablets Warnings/Precautions Warnings/Precautions

Risk of complex sleep behaviors (eg, sleep-walking, sleep-driving, engaging in other activities while not fully awake); discontinue immediately if occur. Monitor for CNS depressant effects and next-day impairment. Evaluate for co-morbid diagnoses (eg, physical and/or psychiatric disorders) prior to treatment. Reevaluate if insomnia fails to remit after 7–10 days of use. Depression. Suicidal tendencies. Evaluate any new onset of behavioral changes. Compromised respiratory function. Sleep apnea. Myasthenia gravis. Drug or alcohol abuse. Hepatic impairment. Avoid abrupt cessation. Write ℞ for smallest practical amount. Elderly (higher risk of falls). Debilitated. Pregnancy (Cat.C). Nursing mothers.

Zolpidem Sublingual Tablets Pharmacokinetics

See Literature

Zolpidem Sublingual Tablets Interactions Interactions

Concomitant other sedative-hypnotics including other zolpidem products: not recommended. Potentiates CNS depression with alcohol, other CNS depressants (eg, benzodiazepines, opioids, tricyclics); adjust dose. May be potentiated by CYP3A4 inhibitors (eg, ketoconazole; consider lower zolpidem dose), sertraline. May be antagonized by CYP3A4 inducers (eg, rifampin). Decreased alertness with imipramine, chlorpromazine.

Zolpidem Sublingual Tablets Adverse Reactions Adverse Reactions

Headache, nausea, fatigue; abnormal thinking and behavioral changes; rare: anaphylaxis, angioedema (do not rechallenge).

Zolpidem Sublingual Tablets Clinical Trials

See Literature

Zolpidem Sublingual Tablets Note Notes

Formerly known under the brand name Intermezzo.

Zolpidem Sublingual Tablets Patient Counseling

See Literature

Promising Long-term Results Of Zolpidem Treatment For The Permanent Vegetative State

Cite this article

Promising long-term results of zolpidem treatment for the permanent vegetative state. Nat Rev Neurol 2, 465 (2006). Https://doi.Org/10.1038/ncpneuro0249

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