Meningitis Vaccine Recommendations
Mastor (30 Mg) (Mirtazapine) Drug Price And Information
Mirtazapine (Mastor (30 mg)) is an antidepressant, prescribed for depression. It alters the activity of certain chemicals in the brain to maintain mental balance.The information provided on this page is intended to serve as a comprehensive resource and should not be a substitute to professional medical advice. If you have concerns it is always best to speak with a healthcare professional.
The information provided on this page is intended to serve as a comprehensive resource and should not be a substitute to professional medical advice. If you have concerns it is always best to speak with a healthcare professional.
Nifedipine - Uses, Side Effects, And More
Who should not use nifedipine?Allergies to Ingredients. People who are allergic to any of the following should not use/take nifedipine.
Your pharmacist can tell you all of the ingredients in the specific nifedipine products they stock.
What should I know about nifedipine before using it?Do not take nifedipine unless it has been prescribed to you by a healthcare provider. Take it as prescribed.
Do not chew, cut, or crush nifedipine extended-release tablets.
Do not share nifedipine with other people, even if they have the same condition as you. It may harm them.
Keep nifedipine out of the reach of children.
Nifedipine can affect your alertness or coordination. Do not drive or do other activities that require alertness or coordination until you know how nicardipine affects you.
What should I tell my healthcare provider before using nifedipine?Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if nifedipine is right for you.
In particular, make sure that you discuss any of the following.
Current and Past Health Conditions. Tell your healthcare provider if you have any of the following.
Pregnancy. It is not known if or how nifedipine could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. Your healthcare provider will advise you if you should take nifedipine while you are pregnant or trying to get pregnant.
Breastfeeding. Nifedipine passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should take nifedipine while breastfeeding.
Ms Contin
Ms Contin Generic Name & Formulations General DescriptionMorphine sulfate 15mg, 30mg, 60mg, 100mg, 200mg; ext-rel tabs.
Pharmacological ClassOpioid agonist.
How SuppliedXR tabs—100
Mechanism of ActionMorphine sulfate is a full opioid agonist and is relatively selective for the mu receptor, although it can bind to other opioid receptors at higher doses. The principal therapeutic action of morphine is analgesia. Although the precise mechanism of the analgesic action is unknown, specific CNS opioid receptors for endogenous compounds with opioid-like activity have been identified throughout the brain and spinal cord and are thought to play a role in the analgesic effects of this drug.
Ms Contin Indications IndicationsManagement of severe and persistent pain that requires an extended treatment period with a daily opioid analgesic and for which alternative therapies are inadequate.
Limitations of UseDue to risks of addiction, abuse, and misuse with opioids (can occur at any dosage or duration); increased risks of overdose and death with extended-release/long-acting opioid formulations, reserve for use in patients for whom alternative treatment options (eg, non-opioid analgesics, immediate-release opioids) are ineffective, not tolerated, or inadequate to provide sufficient management of pain. Not indicated as an as-needed (prn) analgesic.
Ms Contin Dosage and Administration AdultUse lowest effective dose for shortest duration. Swallow whole. Individualize. Opioid-naive: initially 15mg every 8hrs or 12hrs. Opioid non-tolerant: initially 15mg every 12hrs. May adjust dose every 1–2 days. Use 100mg, 200mg tabs, a single dose >60mg, or a total daily dose >120mg in opioid-tolerant patients only. Renal failure, cirrhosis: initiate at lower dose; titrate slowly and monitor. Concomitant CNS depressants: initially 15mg every 12hrs; monitor and consider using a lower CNS depressant dose. Conversion from other morphine formulations or other opioids: see full labeling. Withdraw gradually (esp. If opioid-dependent), taper by ≤10–25% every 2–4 weeks.
Children<18yrs: not established.
AdministrationSwallow whole. Do not crush, chew or dissolve.
Nursing ConsiderationsSwallow whole. Do not crush, chew or dissolve.
Ms Contin Contraindications ContraindicationsSignificant respiratory depression. Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment. During or within 14 days of MAOIs. Known or suspected GI obstruction, including paralytic ileus.
Ms Contin Boxed Warnings Boxed WarningSerious and life-threatening risks from use of MS Contin: Addiction, abuse, and misuse; Life-threatening respiratory depression; Accidental ingestion; Risks from concomitant use with benzodiazepines or other CNS depressants; Neonatal opioid withdrawal syndrome; Opioid analgesic risk evaluation and mitigation strategy (REMS).
Ms Contin Warnings/Precautions Warnings/PrecautionsAssess the potential need for access to naloxone when initiating and renewing therapy. Consider prescribing naloxone based on risk factors for overdose (eg, history of opioid use disorder, prior opioid overdose, household members or other close contacts at risk for accidental ingestion or overdose). Abuse potential (monitor). Life-threatening respiratory depression esp. During initiation or following dose increases. Accidental exposure may cause fatal overdose (esp. In children). Sleep-related breathing disorders (including central sleep apnea (CSA), sleep-related hypoxemia); consider dose reduction if CSA develops. Opioid-induced hyperalgesia (OIH) and allodynia; consider decreasing dose of current opioid or opioid rotation if OIH is suspected. COPD, cor pulmonale, decreased respiratory reserve, hypoxia, hypercapnia, or pre-existing respiratory depression; monitor and consider non-opioid analgesics. Adrenal insufficiency. Monitor for signs of hypotension when initiating or titrating dose. Head injury. Increased intracranial pressure, brain tumors; monitor. Seizure disorders. CNS depression. Impaired consciousness, coma, shock; avoid. Biliary tract disease. Acute pancreatitis. Drug abusers. Renal or hepatic impairment. Reevaluate periodically. Avoid abrupt cessation. Elderly. Cachectic. Debilitated. Pregnancy; potential neonatal opioid withdrawal syndrome during prolonged use. Labor & delivery, nursing mothers: not recommended.
Ms Contin Pharmacokinetics AbsorptionOral bioavailability: ~20–40%.
DistributionVolume of distribution: 3–4 L/kg. Plasma protein bound: 30–35%.
EliminationRenal. Half-life: 2–4 hours (after IV admin).
Ms Contin Interactions InteractionsSee Contraindications. Increased risk of hypotension, respiratory depression, sedation with benzodiazepines or other CNS depressants (eg, non-benzodiazepine sedatives/hypnotics, anxiolytics, general anesthetics, phenothiazines, tranquilizers, muscle relaxants, antipsychotics, alcohol, other opioids); reserve concomitant use in those for whom alternative options are inadequate; limit dosages/durations to minimum required; monitor closely; consider prescribing naloxone if concomitant use is warranted. Risk of serotonin syndrome with serotonergic drugs (eg, SSRIs, SNRIs, TCAs, triptans, 5-HT3 antagonists, mirtazapine, trazodone, tramadol, cyclobenzaprine, metaxalone, MAOIs, linezolid, IV methylene blue); monitor and discontinue if suspected. Avoid concomitant mixed agonist/antagonist opioids (eg, butorphanol, nalbuphine, pentazocine) or partial agonist (eg, buprenorphine); may reduce effects and/or precipitate withdrawal symptoms. May antagonize diuretics; monitor. Paralytic ileus may occur with anticholinergics. May be potentiated by cimetidine, P-gp inhibitors (eg quinidine); monitor. May increase serum amylase.
Ms Contin Adverse Reactions Adverse ReactionsConstipation, dizziness, sedation, nausea, vomiting, sweating, dysphoria, euphoria; respiratory depression, orthostatic hypotension, syncope, OIH and allodynia.
Ms Contin Clinical TrialsSee Literature
Ms Contin NoteNot Applicable
Ms Contin Patient CounselingSee Literature
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