Vaccines for Children: List By Age, Benefits, Safety
Clinical Use Of Cholinergic Drugs In Alzheimer Disease
Cite this articleDesmarais, J., Gauthier, S. Clinical use of cholinergic drugs in Alzheimer disease. Nat Rev Neurol 6, 418–420 (2010). Https://doi.Org/10.1038/nrneurol.2010.105
Share this article Get shareable linkCholinergic Drugs Might Be Effective In Patients With Cerebellar Degenerative Disorders
Cite this articleCholinergic drugs might be effective in patients with cerebellar degenerative disorders. Nat Rev Neurol 4, 351 (2008). Https://doi.Org/10.1038/ncpneuro0820
Share this article Get shareable linkRazadyne Er
Razadyne Er Generic Name & Formulations General DescriptionGalantamine (as HBr) 8mg, 16mg, 24mg; ext-rel caps.
Pharmacological ClassReversible acetylcholinesterase inhibitor (benzazepine deriv).
How SuppliedTabs, soln—contact supplier; ER caps—30
Mechanism of ActionGalantamine, a tertiary alkaloid, is a competitive and reversible inhibitor of acetylcholinesterase. While the precise mechanism of galantamine's action is unknown, it is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by cholinesterase.
Razadyne Er Indications IndicationsMild to moderate Alzheimer's dementia.
Razadyne Er Dosage and Administration AdultGive with AM meal. Initially 8mg/day; if well-tolerated, increase to maintenance dose 16mg/day after minimum of 4 weeks; may attempt further increase to max 24mg/day after minimum of 4 weeks. Re-titrate if interrupted for >3 days. Moderate hepatic or renal impairment (CrCl 9–59mL/min): usual max 16mg/day.
ChildrenNot established.
Razadyne Er ContraindicationsNot Applicable
Razadyne Er Boxed WarningsNot Applicable
Razadyne Er Warnings/Precautions Warnings/PrecautionsDiscontinue at the first sign of skin rash, unless not drug-related; consider alternative therapy if serious skin reactions occur. Conduction disorders (eg, bradycardia, AV block). History of ulcer disease. Bladder outflow obstruction. Asthma. COPD. Seizures. Monitor for active or occult GI bleed, respiratory or neurological effects, and patient's weight. Maintain adequate hydration. Severe hepatic or renal impairment (CrCl <9mL/min): not recommended. Pregnancy. Nursing mothers.
Razadyne Er PharmacokineticsSee Literature
Razadyne Er Interactions InteractionsPotentiates neuromuscular blockers (eg, succinylcholine), cholinesterase inhibitors, cholinergic agonists (eg, bethanechol). Antagonizes anticholinergics. Caution with drugs that slow heart rate. May be potentiated by ketoconazole, cimetidine, paroxetine, fluoxetine, erythromycin, possibly others that affect CYP2D6 or CYP3A4. Monitor for GI bleed with NSAIDs.
Razadyne Er Adverse Reactions Adverse ReactionsNausea, vomiting, diarrhea, dizziness, headache, decreased appetite, anorexia, weight loss, syncope, bradycardia, heart block, seizures; serious skin reactions (eg, Stevens-Johnson syndrome).
Razadyne Er Clinical TrialsSee Literature
Razadyne Er NoteNot Applicable
Razadyne Er Patient CounselingSee Literature
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