20 Pekerja Swasta Diedukasi BNNK Tana Toraja Bahaya Narkoba
15 Statistics On The Anesthesia Industry
Here are 15 statistics on anesthesiologist compensation, debt and more.
This information comes from Medscape's "Anesthesiologist Lifestyle, Happiness & Burnout Report 2023," "Anesthesiologist Compensation Report 2023" and "Physician Wealth & Debt Report 2023.
Burnout and mental health
Compensation
Wealth and debt
Miscellaneous
Psychedelics And Anesthetics Cause Unexpected Chemical Reactions In The Brain
The brain is the most complex part of the human body. To keep our heads running smoothly, more than 100 types of neurotransmitters must shuttle messages across multiple regions of white and gray matter. It's difficult for researchers to track the immense number of connections that these chemical messengers make—Google recently created one of the most detailed maps of neuronal connectivity patterns, but even the tech giant could only focus on a small section of the brain.
While it may take decades until someone fully maps out the human brain, there are ways to trace different aspects of connectivity. A new study published today in Science Advances used mind-altering drugs, such as ketamine and the surgical anesthetic propofol, to follow which neurotransmitter systems those pharmaceuticals activate. The findings help identify associations between these drugs and unexpected neurotransmitters. They could also help identify new treatment options for certain conditions and diseases, as the authors found that brain regions commonly altered by different drugs were often similarly affected by various neurological disorders.
Pharmacological agents such as mind-altering drugs have powerful uses in medicine, says Andrea Luppi, a postdoctoral researcher of network neuroscience at the Alan Turing Institute in the United Kingdom. "Anesthetics are extremely useful for surgery. Modafinil and methylphenidate are used to treat certain conditions," Luppi says. "So it's important to know how they act on the brain to exert their effects."
But these types of chemicals can be tricky to understand, because they activate more than one neurotransmitter receptor. Knowing how they work in the brain can improve how they are used in clinical practice in the future. But it's not enough to predict a drug's mechanism based purely on its clinical effects. There is also a chance these drugs could influence other neurotransmitters beyond their main targets.
[Related: If you grow a brain in a lab, will it have a mind of its own?]
To address these questions, Luppi and his coauthors analyzed two sets of neuroimaging data from past studies to map out the ways the human brain changes when taking 10 mind-altering drugs. These drugs fell under three categories: psychedelics (psilocybin, DMT, LSD, MDMA, ayahuasca, and ketamine), anesthetics (propofol and sevoflurane), and cognitive enhancers (modafinil and methylphenidate). The first data set, based on the PET scans of 1,200 people, helped the team sketch out 19 types of molecules in the brain: all neurotransmitter receptors and transporters.
Using fMRI scans, the study authors can examine brains in their normal states and under the effects of mind-altering drugs. Luppi et al./Science AdvancesThe second dataset used the fMRI scans of 224 people who had acute exposure to one of the 10 drugs. According to the authors, this is the largest fMRI study to date that has plotted a detailed map of the neurotransmitter landscape when under the influence.
Brain mapping showed that mind-altering drugs work with multiple neurotransmitter systems. The mapping showed expected relationships, such as the link between MDMA and its well-known target, the serotonin 2A receptor. However, the team noticed some mind-altering drugs, like anesthetics and psychedelics, can affect other neurotransmitters beyonds their main molecular targets. For example, anesthetics at the lowest dose primarily target molecules in the brain called GABAA receptors. But the molecules that the drugs bind to changes as doses increase, the authors found, activating a more diverse group of neurotransmitters.
[Related: How your brain conjures dreams]
"We are used to thinking that many drugs have a single or few molecular targets. What we see suggests that even when a drug exerts its effect through a specific receptor, it can have downstream consequences on many neurotransmitter systems. This reinforces the idea that the brain is a complex system," Luppi says.
According to the study authors, their mapping provides new opportunities to explore how each of these mind-altering drugs affects the neurotransmitter landscape. It could also help vet certain drugs for neuropsychiatric treatments. The changes in activity caused by mind-altering drugs are similar to the changes seen in the brains of patients with conditions such as autism, depression, and schizophrenia, the authors say. Administering mind-altering drugs that rewire the connections in functionally impaired brain areas could be another treatment option for people who live with these conditions.
How Anesthesia Techniques Can Help Or Hinder Reimbursement For Post-op Pain Blocks
When and how procedural anesthesia and postoperative pain blocks are administered often play a role in procedure reimbursements for care.
There are various POP blocks available for anesthesiologists and patients, from epidurals and spinals to peripheral nerve blocks.
And for some physicians, the ability to be paid for these blocks is tied to the anesthesia technique used in the case, according to a May 30 blog post from Rita Astani, president of anesthesia for Coronis Health.
POP blocks and general anesthesia:
When general anesthesia is used, POP block reimbursement is typically easy. If it's a block approved by the payer, it does not matter if it is placed preoperatively or postoperatively. Reimbursement for postoperative placement can change if the anesthesia is anything other than a general.
Regional POP blocks:
When using a regional block as the main anesthetic, obtaining reimbursement for postoperative pain procedures becomes more difficult. If the mode of anesthesia is a regional block, you cannot bill separately for postoperative pain when the POP block is the same as the block used for interoperation.
If you used an epidural for the case anesthetic, you cannot additionally bill for a POP epidural. If the mode of anesthesia is either a general, spinal or epidural, you can bill a peripheral nerve block separately for postoperative pain.
Using monitored anesthesia care:
Providers may not bill separately for peripheral nerve blocks for postoperative pain management when their anesthesia mode is monitored anesthesia care.
Authors of Medicare reimbursement codes believe that a postoperative pain procedure performed prior to, or during, the surgery provides some measure of anesthetic relative to the operative session. Therefore, it is inappropriate to bill for postoperative pain separately.
If physicians perform the POP block after the surgical session where MAC was used as the mode of anesthesia, the door is open for a separate payment.
Comments
Post a Comment