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Finasteride Lowers Risk Of Prostate Cancer But Increases Risk Of High-grade Tumors
Finasteride prophylaxis appears to prevent or delay the onset of prostate cancer, however, finasteride may also accelerate the growth of high-grade cancers.More than 18,000 men were randomized , age 55 or older to finasteride 5 mg/day or placebo. At baseline, digital rectal examination results were normal in all subjects, and prostate-specific antigen (PSA) levels were no more than 3.0 ng/mL. Among the 4368 men in the finasteride group treated for 7 years, prostate cancer was detected in 18.4%, compared with 24.4% of the 4692 assigned to placebo group, a significant difference (pTreatment was temporarily discontinued by 18.3% of subjects administered finasteride and 9.8% of those given placebo because of side effects. Finasteride was more likely to affect sexual functioning, whereas placebo was more likely to be associated with genitourinary effects.
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For a man considering using this medication, the greater absolute reduction in the risk of prostate cancer must be weighed against the smaller absolute increase in the risk of high-grade disease,say doctors.Researchers, suggests that "finasteride may have created an environment in which high-grade cancers that were less dependent on androgens for their growth had a competitive advantage."
According to doctors , "Finasteride does not seem to be an attractive agent for the chemoprevention of prostate cancer." However, they do not advocate discontinuation of the drug when used to treat urinary symptoms, so long as patients undergo careful monitoring.
Finasteride Reduces Serum PSA To A Similar Extent At 1 Mg And 5 Mg Daily Doses
Cite this articleFinasteride reduces serum PSA to a similar extent at 1 mg and 5 mg daily doses. Nat Rev Urol 4, 179–180 (2007). Https://doi.Org/10.1038/ncpuro0746
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